The phrase "across the developmental time" is not correct in standard written English.
It may be intended to refer to changes or processes that occur over a period of development, but the phrasing is awkward.
Example: "The study examines the changes in behavior across the developmental time of the subjects involved."
Alternatives: "over the course of development" or "throughout developmental stages".
Clustering of gene expression profiles across the developmental time series was performed in GeneSpring using the K-means algorithm.
Here we have outlined the common patterns of gene expression across the developmental time course and have correlated these patterns with biological function.
The proportion of Caenorhabditis-restricted genes across the developmental time course examined by Levin et al. [ 61] varied from 36%to60%0%.
To investigate if these enhancers become active later in development, we calculated H3K27ac enrichment at Class II sites across the developmental time points where modENCODE has mapped this modification by ChIP-seq (Additional file 3: Figure S2).
A cluster analysis designed to describe the most prominent general patterns of gene expression across the developmental time-series revealed eight different gene expression profiles: for example, one group of genes showed low expression early in development, a peak of higher expression at intermediate stages, and decreasing expression levels later in development.
Instead, the developmental time course we found resembles those of other cues, both within and across modalities [ 8, 9, 20], raising the possibility of a maturational bottleneck.
Based on their transcript levels across the five developmental time points, the 3081 spots could be grouped in 6 clusters, formed by 796, 631, 812, 555, 125 and 162 spots, respectively.
Clusters of the differentially expressed genes were defined by a four letter combination of the following categories across the whole developmental time course: Flat (F, no significant change); Up (U, significantly up-regulated), and; Down (D, significantly down-regulated).
We tested this hypothesis by doing qPCR for the 19 glycosyl hydrolases across the four developmental time points on ida mutant receptacles and a new set of wild type receptacles.
Among genes associated with chimeric development, nearly half were differentially expressed at specific developmental stages instead of across the entire developmental time course.
Whereas aggressive behavior, irritability, and psychomotor changes decrease across the two developmental time periods, depressed mood, worthlessness and hopelessness and guilt increase.
