Exact(2)
An updated report on the phase I clinical trial (KEYNOTE-001) included the analysis of 411 melanoma patients treated across multiple dose levels.
Other attempts to analyze patients with melanoma have been reported, including an analysis of 411 melanoma patients treated across multiple dose levels and multiple trials, which was reported at the 2014 ASCO Annual Meeting.
Similar(58)
The drug was well tolerated at each single or multiple dose level.
Wagner, F., Skrumsager, B. K. & Fitilev, S. Safety and tolerability of NNC01140006, an anti-IL-21 monoclonal antibody, at multiple s.c. dose levels in patients with rheumatoid arthritis.
The validity of the model is supported by the good prediction of the complicated PKs observed in the clinical study described in this article, which included both single and multiple dosing regimens ranging from 5 to 240 mg across 9 dose levels.
In XL647-002, 31 patients were enrolled across 5 dose levels.
Patients remained on study until progressive disease or unacceptable AEs.RESULTS: In XL647-001, 42 individuals were enrolled across 9 dose levels.
The humoral immune response increased to a peak at the 5.0 μg/ml dose while the cellular immune response increased across all dose levels.
It was rapidly absorbed with peak plasma concentration achieved in approx. 2 h across all dose levels.
To determine the relationship of acute changes in Na+ channel-related parameters with oxaliplatin dose levels, comparisons were made across different dose levels.
Responses and durable SD were seen across all dose levels.
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