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Limitations may stem from the wide differences in MTX dosing across different trials.
Accordingly, we caution that the comparison of exercise and drug interventions should be tempered by the additional differences in patient populations across different trials.
However, in both cases, the authors did not attempt to fully account for the differences in different sources of heterogeneity, including baseline patient characteristics across different trials.
An additional complication is the possibility that a study site is inconsistent across different trials.
In the incongruent condition, stimulus pairs reversed their status as discriminative stimulus or outcomes across different trials.
Several CAR designs across different trials have generated similar response rates, with Complete Response (CR) of 60 90% at 1 month and an Event-Free Survival (EFS) of 70% at 6 months.
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Assuming that the absolute treatment difference (point difference) is the same across different trial scenarios implies that a treatment can give X points benefit no matter how much the placebo group declines, how sensitive the instrument, or how heterogeneous the population being studied.
In Alzheimer's disease, use of the method assumes that the treatment is expected to reduce the decline by the same percentage across different trial scenarios.
With standardized biomarkers to look at and harmonized assays to test them across many different trials, data from different studies will be more easily compared, Collins said.
This is a reasonable correlation for traits across two different trials conducted some years apart.
In addition, we tried to determine the reason for the heterogeneous results across the different trials.
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