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"They wanted to figure out why, and apply that learning across centers, and they were convinced culture must have something to do with it," he explains.
However, there is a significant imbalance across centers.
For comparison, we also show results from pooling all observations across centers and ignoring the underlying heterogeneity across centers.
It has been difficult to compare the data across centers; however, some common themes have emerged.
The mortality rate was 30%% (n = 23), with no difference across centers.
Co-interventions were harmonized across centers according to 2008 Surviving Sepsis Campaign guidelines [22].
Protocols may also help reduce heterogeneity of treatment across centers in clinical trials.
Error tolerance limits are not well-defined or consistently applied across centers.
As such, counselling is imprecise and management varies substantially across centers.
In the absence of guidelines, indications of RBC transfusion in this setting were probably quite inconsistent across centers.
Pooling observations from multiple centers creates the added difficulty of appropriately accounting for heterogeneity of services in SU across centers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com