The phrase "across breed" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to something related to different breeds, but the phrase lacks clarity and proper usage.
Example: "The study focused on the genetic variations found across breed lines in dogs."
Alternatives: "among breeds" or "between breeds".
Bannasch, D. et al. Localization of canine brachycephaly using an across breed mapping approach.
As a note of warning, especially for across breed association studies, precautionary measures to avoid spurious associations due to population stratification have to be taken40.
Many dog breeds share mutations causing common traits and several phenotypes have been mapped by using an across breed mapping approach8,16,23,24,25.
Across breed power studies were not possible due to the low number of SNPs that followed the expected fixed trait distribution.
These genomic intervals can be refined by using an across breed validation strategy.
In all four across breed mapping examples, a p value of <0.05 would identify false positive chromosomal locations.
Figure 2 shows the proportions of additive genetic variance explained by each of the across-breed and breed-specific pleiotropic QTL; and all other identified QTL.
Studies on beef cattle across-breed predictions are limited [ 14, 15], but accuracies of g.CIMF and g.WW reported here were in the same range than those in [ 15].
GBLUP estimates of ASEs from the across-breed analysis were moderately correlated (0.31 0.66) with those from the individual within-breed analyses, indicating that prediction equations for molecular estimates of breeding value developed from across-breed analyses should be effective for genomic selection within breeds.
Most estimated genetic correlations for the across-breed trained molecular breeding values were moderate (> 0.30).
Even for closely related breeds, within- or across-breed trained molecular breeding values have limited prediction accuracy for breeds that were not in the training set.
