The phrase "across approach" is not correct and does not convey a clear meaning in written English.
It may be intended to describe a method or strategy that spans multiple areas or perspectives, but it lacks clarity and standard usage.
Example: "The across approach to problem-solving allows us to consider various viewpoints and solutions."
Alternatives: "cross-functional approach" or "holistic approach".
Mammalian pharmacological and toxicological information were used to guide the experimental design and the selection of relevant endpoints, according to the so-called "read-across approach", suggesting that dutasteride may affect male fertility and steroid hormone dynamics.
In summary, the overall REACH criteria for applying a read-across approach are met.
The models can be later used either for direct prediction of the endpoint under consideration for new, i.e. untested compounds, or for read-across approach.
Iteratively, one molecule at a time was left out of the dataset to be predicted using our read-across approach on the remaining molecules.
These rules will be implemented into the ToxRead software [32], a new freely available tool that assists users in read-across approach.
According to REACH Annex XI 1.5 (grouping of substances and read-across approach), the aim of a read-across is to avoid testing of every substance for every endpoint using data known for one substance for other, similar substances.
We chose to use, for the batch process, a read-across approach on two distinct datasets, in order to find an acceptable criterion of choice of elements and weighting scheme for the similarity index in a generic application.
Similarly to the the first step, we calculated the utility and desirability values considering both the R2 and RMSE of the read-across approach on the two datasets, and ranked the combinations.
One common application of chemical similarity measurements, based on the principle that similar molecules have similar properties, is the read-across approach, where an estimation of a specific endpoint for a chemical is provided using experimental data available from highly similar compounds.
When chemical-specific estimates are lacking, the range of interindividual variability for structurally related compounds may be informative, in a read-across approach.
