The sequential acquisition of the techniques reduces the problems related to the lack of alignment and the change of position of the patient.
The order of acquisition of the techniques in each group was well predicted by relative rank order (Spearman's rho = 0.81, df = 19, p<0.001; Table 1).
Aside from issues such as obscuring biological material, the image will have been subjected to aberrations linked to the modality of the acquisition technique 3. The process of dealing with these degenerative effects can often become very complicated.
You will notice some step artifact in the resultant models, relating to the acquisition technique for the original images, not optimized for 3D printing – namely, not highest resolution possible isotropic reconstructions.
However, such tools were developed long time ago for grey-scale small-size images, but due to the evolution of the acquisition techniques the spatial resolution significantly increased and, in addition, the world of images became coloured.
Clinical validation studies have shown conflicting results, partially due to variations in signal acquisition inherent in the technique [ 45 ].
We excluded variance of individual animals, only the factors related to the acquisition technique were taken into account, which included the effect of the imaging protocol and the instrument.
One of the aspects revealed by this study that although the reliability of the acquisition technique is high, a shared, user-friendly protocol of imaging analysis is not available yet although this would be mandatory to allow comparison of results.
The acquisition technique is important to maximise the ability of the study in the diagnosis and classification of patients.
The calibrated approach seeks to nullify uncertainties (or variation) introduced by the acquisition technique differences by producing standardized data, often with the aim of making comparisons with PD.
