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GWAS are limited because the cost prohibits acquisition of the sample size needed to overcome the multiple testing problems inherent in gene-gene analyses.
The follow-up observation period after acquisition of the sample is 6 months.
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This was done with a tissue arrayer (Beecher Instruments, Silver Spring, MD, USA) Two 1mm diameter cores from the same tumor were arranged side by side onto the recipient block to minimize any heterogeneity during the acquisition of the samples with the arrayer.
YX participated in the acquisition of the samples.
SW participated in the acquisition of the samples.
Acquisition of the samples was performed on a flowcytometer.
XH organized the epidemiological field study and participated in the acquisition of the samples.
The acquisition of the samples and their subsequent examination were approved by the Institutional Review Board of Chung Shan Medical University.
All authors contributed to the acquisition of the samples or study data.
SMP and NRS were involved in fractionation and mass spectrometry-based data acquisition of the samples.
We note that the time between ligation and the acquisition of the samples varied across the different independent datasets.
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