The phrase "acquisition of substrate" is correct and usable in written English.
It can be used in contexts related to biology, chemistry, or materials science, where it refers to the process of obtaining or taking in a substrate for a reaction or process.
Example: "The acquisition of substrate is a crucial step in the enzymatic reaction that drives metabolic processes."
Alternatives: "obtaining substrate" or "gaining substrate".
Guided by the structural homology, we show that UlaG is able to cleave phosphodiester linkages in cyclic nucleotides, suggesting that the conservation of the fold and of the key catalytic residues allows for the evolutionary acquisition of substrate specificity for novel but related substrates.
Likewise, the atypical BChEs show different intermediate patterns of substrate inhibition or lack thereof, which could be interpreted as a transition to the complete loss of substrate inhibition with all substrates, and the acquisition of substrate activation, also a property consistent with the detoxifying role of BChE.
What does the catalytic landscape look like as an enzyme family traverses all possible lineages en route to the acquisition of new substrate and/or product specificities?
Acquisition of novel substrate specificities by proteases often leads to broad-specificity variants by initially favoring mutations that increase the conformational flexibility and destabilize specialized active site structures.
It will be insightful to decipher the key components regulating the metabolic machinery, in particular, those promoting the acquisition of permissive substrate utilization patterns that fuel disease progression and enable malignant transformation.
Although, we have not tested the FA specificity of the novel Acsl repertoire described in this work, we cannot ignore that the retention of a larger Acsl gene number in teleosts could also be related with the specific acquisition of novel substrate preferences, which future studies should address.
Thus expression of specific F1SBPs in B. infantis may play a role in acquisition of food substrates as well as assist in adherence to glycoconjugates on epithelial surfaces.
While unliganded (apo) structures provide some information that can be used to help understand mechanism, the acquisition of complexes, with substrates (or substrate analogues), sugar-shaped inhibitors, mechanism-based inhibitors, or products have the potential to reveal intricate details of the amino acid residues involved in catalysis and the conformations of enzyme-bound species.
Remarkably, this property was linked to the acquisition of a new substrate selectivity profile similar to that of factor Xa, a Na+-activated protease involved in blood coagulation.
The current understanding of substrate acquisition by Hsp90 is markedly different.
These include modulation of membrane fatty acid composition, oxidative and lytic stress protection, acquisition of new available substrates, transport functions including heme/iron transporters and genes associated with virulence in E. faecalis.
