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Chromosomal and genomic instability has been detected in several hESC lines, with acquisition of loss of heterozygosity or copy-number variation in cancer-related genes [ 81, 82].
Using the array and analysis tools, we constructed a haplotype map (hapmap) of strain SC5314 to assign SNP alleles to specific homologs, and we used it to follow the acquisition of loss of heterozygosity (LOH) and copy number changes in a series of derived laboratory strains.
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However, the most frequent pathway that leads to the mucoid phenotype is the acquisition of loss-of-function mutations in a single gene, mucA, which encodes for a negative regulator of alginate production [18].
Rates of escape acquisition and of loss of transmitted virus suggest CD8+ T lymphocytes are likely to have a direct role in virus containment early in natural infection, providing further impetus for continued exploration of vaccines that induce CD8+ T-lymphocyte responses [38], [34], [35].
The acquisition of the loss-making Bulgari seems to have been consensual.
Analysts say Walmart's acquisition of the loss-making startup is an admittance that the retailer's online efforts are failing to make headway.
Poundland, which faces a possible takeover bid from the South African conglomerate Steinhoff, has reported a sharp fall in profits, following the £55m acquisition of its loss-making rival 99p Stores.
Due to the complexity of its randomness of acquisition or loss of genetic traits, we can not explain yet how the fate or plasticity of cancer cells is exactly affected by the cell fusion procedure.
The latter showed a continuum of marker expression and displayed a reproducible pattern of acquisition and loss of normal antigens during B-cell maturation.
Here we will consider the patterns of acquisition and loss of the external protein coding segments on the backbone of each internal protein coding segment, since this represents the mechanism for generating antigenic novelty in a circulating population of viruses from the perspective of the internal protein coding segments.
Here, in simple terms, treatment frequency dynamics are typically dominated by two processes, representing the rates of acquisition and loss of remedies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com