Hypercoagulable states are inherited or acquired predispositions to venous or arterial thromboses that are best understood in the context of the coagulation cascade.
He advocated that human disease is not a state as we frequently refer to "disease state" but rather a process which is complicated by numerous factors such as genetic predisposition, acquired predispositions to disease, co-morbidity, length of disease since diagnosis, treatment history, diverse response to a given therapy and other yet unspecified modifiers.
In irradiated leukaemia cells, resistance to radiotherapy was acquired without 'clonal predisposition' (Lee et al, 2010; Lagadec et al, 2012).
The reasons behind this differential response to TAE684 are presently unclear, but may indicate differences in genetic background, or reflect complex genetic predispositions acquired by these cells.
Thus, both genetic and non-genetic predisposition and acquired alterations in taste and reward functions appear to work in concert to aggravate palatability-induced hyperphagia.
Idiopathic CD is often dependent on a genetic predisposition, while acquired CD results from trauma to either the central or peripheral nerves controlling the neck muscles.
We hypothesised that hospital acquired hyperglycaemia reveals this predisposition, that is, those patients are at risk for developing type 2 diabetes in the period subsequent to acute illness.
Additionally, partners who stay negative after longer periods of time in a serodiscordant relationship may have reduced susceptibility of some kind, such as having a protective genetic predisposition or acquired immunity through repeated exposure [ 23].
Older age, genetic predisposition, other acquired medical conditions, stress and emotions are factors that may contribute to various deficiencies observed in AD such as memory loss, impaired learning, and dementia or to more ominous threats like Parkinson's and Alzheimer's diseases [ 1, 2].
