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To date we have acquired follow up data on 1,187 patients; specifically, information on the staging, management and clinical outcome permitting comparison patients randomly drawn from the general population.
IQ patient's management; design and manuscript draft LS patient's management; help with manuscript draft and figures NB endoscopy, reviewed history and acquired follow up data of patient DT analysed tissue samples and provided figures LR reviewed manuscript and literature BH design, coordination and supervision of patient's management All authors read and approved the final manuscript.
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In common with other forms of allergy the disease progresses in two stages; an initial phase during which sensitization is acquired, followed later (after subsequent exposure to the same chemical allergen) by elicitation of a cutaneous inflammatory reaction.
The patients were injected with 1-[11C]-acetate (5.0 MBq/kg body weight, mean dose 436 MBq, range 304 to 577 MBq) i.v., and a CT scan with low dose for PET attenuation was acquired, followed by a PET scan 10 min post-injection and finally a diagnostic CT with or without i.v. contrast media.
A digital grayscale animal image was acquired followed by acquisition and overlay of a pseudocolor image representing the spatial distribution of detected photons emerging from active luciferase within the animal.
The fMRI paradigm consisted of 8 inflation and deflation cycles consisting of a 90 s baseline period with the balloon deflated ('off'), during which time 9 images were acquired, followed by a 30 s activation or inflation period ('on'), during which 3 images were obtained, for a total of 16 min and 96 images for each pressure (40 or 60 mmHg).
On day 6 or 7 after virus inoculation, [C]CB184 PET scans were acquired followed by ex vivo evaluation of biodistribution.
Proton density-weighted images were acquired, followed by a series of T1-weighted images employing the same gain and image scaling factors.
The instrument was operated in the 'top three' mode, in which one MS spectrum is acquired followed by MS/MS of the top three most intense peaks detected.
A 15-minute emission scan was acquired followed by a 400-second transmission scan, using the built-in Co source (energy window 120-125 keV) for attenuation correction.
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