The phrase "acquired dependence" is correct and usable in written English.
It can be used to describe a state of reliance that has developed over time, often in the context of addiction or habitual behavior.
Example: "The study revealed that many individuals develop an acquired dependence on certain substances after prolonged use."
Alternatives: "developed reliance" or "established dependence."
The altered metabolic state of cancer cells and the acquired dependence on specific metabolic processes such as glycolysis provide an additional level of targetable molecular addictions.
One possible explanation for the evolved strains' acquired dependence upon citrate would be a defect in either production or uptake of iron chelating siderophores.
This increased sensitivity to rapamycin suggests that GDF15-over-expressing ovarian cancer stable clones may have acquired dependence upon mTORc1 signaling.
This interaction was due to an acquired dependence on citrate to carry out a function that populations have lost, which contrasts with the gain of novel function observed in the Cit+ A-3 population.
Oncogene addiction, that is, the acquired dependence of a cancer cell on the activity of a single oncogenic gene product, has been the basis for the targeted therapy paradigm, and operationally defines such signals.
In order to test for acquired dependence upon citrate (i.e., rule out H0), we compared growth rate and yield on glucose either with or without citrate for the ancestors and one clonal isolate from each of the 12 populations of the LTEE at 50,000 generations.
This example, in stark contrast to our model, highlights the signaling complexity inherent in cancer, and the ability of tumor cells to acquire dependence upon discrete components of eHsp90's signaling repertoire.
But a month later Waksal's lawyers told the feds he had recently developed a "dependence on alcohol" and would benefit from treatment for his newly acquired addiction.
Analysis using BH3 profiling confirmed that spheroids acquired a dependence on anti-apoptotic Bcl-2 proteins and were 'primed for death'.
We show that in addition to the citrate-catabolizing strain, three other lineages evolving in parallel have acquired a dependence on citrate for optimal growth on glucose.
By performing high-throughput loss-of-function genetic screens that exploit RNA interference technology [ 58], Gilliland and colleagues [ 59] showed that tumor cells with mutant RAS have acquired a dependence on the kinase STK33; tumor cell molecular networks have been rewired such that STK33 now becomes critical whereas it is not in normal cells.
