"acquired alteration" is correct and usable in written English.
You can use this phrase when you want to emphasize changes that were caused by some external force or gained through experience. For example, "The language has undergone several acquired alterations over the centuries."
Over 80% of GBMs have an acquired alteration in the RTK/PI3K/AKT pathway with ∼40% of tumors having some alteration in EGF-R.
Although this may be an acquired alteration in these children instead of a structural problem in former preterm infants, these results at least show the feasibility of detecting alterations before clinical complications.
81 This acquired alteration increases the ATP binding affinity of EGFR approximately 10-fold in the presence or absence of a TKI allowing ATP to competitively displace gefitinib and erlotinib from EGFR.
In addition, MMR deficiency may result from genetic disorders, caused by an inherited germ-line mutation of one allele followed by an acquired alteration of the wild-type allele leading to inactivation of one of the three main MMR genes (MLH1, MSH2, and MSH6) [ 7].
A number of recent reports utilizing circulating free DNA have correlated the occurrence of EGFR resistance with the acquirement of mutations in both KRAS and NRAS, as well as other acquired alterations such as EGFR mutation or MET amplification [ 3, 25, 26].
Inherited or acquired alterations in the mismatch repair genes allow mutations specifically point mutations and changes in the lengths of simple sequence repetitions to accumulate rapidly (behaviour referred to as a mutator phenotype).
Several different tests have been used to study acquired alterations of color vision.
Of interest, many of these acquired alterations occur in human astrocytomas, further validating GFAP-RAS as a useful model for studying astrocytoma development and progression.
Thus, both genetic and non-genetic predisposition and acquired alterations in taste and reward functions appear to work in concert to aggravate palatability-induced hyperphagia.
Hysterosalpingography (HSG) is the routine evaluation technique of the uterine cavity to determinate congenital or acquired alterations; normally when we suspect uterine pathology by HSG we proceed to do a hysteroscopy.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare condition resulting from acquired alterations in the PIGA gene, which plays a role in the protection of blood cells from the complement system.
