Sentence examples for acquire trail from inspiring English sources

However, the most dramatic changes in gene expression occurred between 8 and 16 h when pretransformed cells acquire TRAIL sensitivity.

Unfortunately, gliomas and other cancers acquire TRAIL resistance through a variety of molecular alterations that include mutations in the receptor complex, expression of decoy receptors and overexpression of survival factors.

Notably, loss of Bax, despite expression of Bak, is sufficient for tumor cells to acquire TRAIL-resistance.

This acquired TRAIL sensitivity was blocked by AMD3100 pre-treatment of the cells (p<.01), confirming that the TRAIL sensitivity was mediated by gp120/CXCR4 interaction.

Mounting evidence confirms that XIAP, the most potent anti-apoptotic protein among IAPs, is responsible for primary or acquired TRAIL resistance in tumor cells [ 13- 16].

In that regard, even though combining TRAIL-based approaches with multiple therapeutic agents improves the apoptotic response and diminishes the chances to generate resistance, only proteasome inhibitors were shown to revert acquired TRAIL resistance.

However, primary or acquired resistance of glioblastoma toward TRAIL calls for alternative approaches to restore TRAIL sensitivity.

The Trail Blazers acquired Voshon Lenard from the Nuggets and Brian Skinner from the Kings.

Ms. Palin denied, vehemently and in detail, that she had any role in requesting or obtaining the $150,000 wardrobe that she and her family acquired on the campaign trail.

He also pointed out the city acquired part of the trail from a resident in 1991, and building a new path if the current trail collapses would be a challenge.

Roughly $400,000 in funding to convert the corridor to a trail was acquired through an easement from the town of Lloyd to a broadband utility for the laying of fiber optic cable, though only $70,000 was needed to pave the trail.