Yet this does not exclude that, at least in some case, the metastatic phenotype is acquired by an additional mutation by a single cell in the primary tumor or by a cell that, although devoid of metastatic growth characteristics, acquires this potential through mutations.
Most importantly, only cells at this predifferentiation arrest state acquire the potential to differentiate without undergoing DNA synthesis.
The identification of these cellular proteins will help to elucidate the mechanisms by which the viruses acquire the potential to become pandemic in the human population.
During neurogenesis, clusters of 12 20 cells first acquire the potential to become neuronal cells.
Rather, our data suggest that nuclei of non-muscular origin acquire the potential to bind centrosome proteins, once exposed to a differentiated, muscular environment.
In zoonotic infections, although many interspecies transfers are dead ends, sometimes viruses evolve through mutation, recombination, or reassortment and acquire the potential to spread from human to human.
Cancer cell populations lose their ability to negatively regulate cell cycle leading to uncontrolled cellular proliferation and acquire the potential to evade apoptosis consequently, diminished cell attrition [ 5].
The formation of a figure-eight-like structure occurs within the inhomogeneity; this later disappears and the medium acquires the potential to support more than one scroll; hence the existence of three filaments is observed.
In the case of deregulation, TBX3 also acquires the potential to become an oncogene in melanoma cells14.
In fact, enclaves were quite common before modern national borders became significant [8], which is when they acquired the potential to wreak geostrategical havoc.
