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There are a few recurring figures who acquire the specificity of fingerprints: one thinks especially of the bicyclist who found Mr. Shepard, embodied with eloquent inarticulateness by Kelli Simpkins, and the deputy sheriff, vibrantly played by Mercedes Herrero, who is exposed to H.I.V. while assisting the wounded Mr. Shepard.
So sometimes they accumulate 50 somatic mutations before they acquire the specificity and affinity of a broadly neutralizing antibody.
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Whereas some of these proteases share a common origin with mammalian cell encoded hydrolases with specific properties towards Ub/Ubls, most of them have ancient intrinsic functions, such as processing pathogen protein components, and may have acquired the specificity for Ub/Ubls by interacting with mammalian hosts and their immune system throughout evolution.
Finally, the designed chemical scaffold for a drug lead has to be supplemented with hydrogen-bond acceptor and/or donor groups at certain positions to acquire the desired specificity by interactions with the side chains of N111 and N115 and backbone amide and carbonyl groups.
The ending step of PCR is performed to acquire the dissociation curve, validating the specificity of the PCR products.
The final PCR step was performed to acquire the dissociation curve, validating the specificity of the PCR products.
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More importantly, some H9N2 viruses have acquired the typical receptor specificity of human influenza viruses, and have been transmitted directly to humans causing mild respiratory disease [4], [5].
For example, in the case of the glucocorticoid receptors, it was inferred that neutral mutations that stabilized a new conformation must have been acquired before the specificity-shifting mutation could arise in the receptor's active site (Ortlund et al., 2007).
After amplification, a melting curve was acquired to check the specificity of PCR products.
The cutoff points were calculated by acquiring the best Youden index (sensitivity + specificity − 1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com