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The system uses a gamma camera to acquire projections data that are detected using a parallel hole collimator.
The frame of the anvil cell blocks the incoming beam for many projection angles, making it impossible to acquire projections for the entire 180 ^circ) range.
These compact detectors have made it possible to mount multiple detector-pinhole units in a static geometry to acquire projections simultaneously with an angular coverage sufficient for tomographic reconstruction.
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Ectomography is a limited view angle method, using a rotating slant hole collimator and a stationary camera head, to acquire projection images.
A reflected-light microscope could be applied with a low NA in the detection path and extended by a rotation stage to acquire projection images of scattered light as presented in the results section.
The goal of iterative reconstruction is to find the best estimated slice that, when projected in multiple directions, is as close to acquired projections as possible.
Note that the required computation time of FBP and iterative methods generally scales linearly with the number of acquired projections.
Gamma camera projections were Monte Carlo simulated, representing clinically acquired projections of a patient who had inhaled 125 MBq 99mTc-Technegas followed by a 10-min SPECT examination.
At the same time, the acquired projections are often limited in some way, for example having a low number of projections or a low signal-to-noise ratio.
To enable direct feedback and optimization of experimental parameters, it is important that the acquired projections can be processed in a time comparable to data acquisition.
Due to the limited number of counts in the acquired projections there are fluctuations inside the lung even for the simulated normal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com