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During CRC development, epithelial cells acquire peculiar features which enable them to grow aberrantly, ignore growth inhibition, and resist death signals [ 44].
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At a more local level, the substantial diversification of the Cul4 sequences in some fungi, especially the saccharomycotina, may also be an indication of them having acquired peculiar functional features.
Since ovarian cancer cells often acquire a peculiar phenotype which includes up-regulation of E-cadherin expression in contrast to its absence in normal OSE [4], we hypothesized that these cells may penetrate/invade through ECMs using alternative strategies to the well-studied mesenchymal cell migration.
The slave trade acquired a peculiar importance to Britain's colonial economy in the Americas, and it became an economic necessity for the Caribbean colonies and for the southern parts of the future United States.
Mr. Narasin speculates that Fashionmall had acquired such peculiar interest because it had stashed away at least $35 million in cash -- more than the company's entire market value at the time of Narax's offer.
There was a dignified conclusiveness - not to say a grand convenience - in this way of getting rid of undesirables_ Mr Podsnap had even acquired a peculiar flourish to his right arm in often clearing the world of its most difficult problems, by sweeping them behind him (and consequently sheer away).
An individual's mind is introduced "into a self-contained world" and acquires a peculiar mystagogy.
Low observed the effect of the island's climate on the inhabitants: "The men are stout hardy spadesmen as was said before, the women while young are tolerably well looked, but as they advance in age grow very hard favoured, acquiring a peculiar ghastliness in their countenances contrary to what is observed of the women in Orkney".
In this context, variability at these loci acquires a peculiar relevance.
Things quickly get peculiar.
Everything seemed to have acquired its own peculiar heft and strangeness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com