The phrase "acquire driver" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to obtaining a driver, such as a software driver or a person who drives, but it lacks context for proper usage.
Example: "To ensure the printer works properly, you need to acquire the correct driver from the manufacturer's website."
Alternatives: "obtain driver" or "get driver".
10.7554/eLife.06266.028 Appendix 1 figure 4. Sensitivity analysis of ( A ) the mutation rate to acquire drivers and ( B – D ) initial tumour size.
A mutator cell then acquires driver mutations faster than its nonmutator counterparts, and so the mutator phenotype indirectly bestows a selective advantage.
Although it is clear that not all cells harboring driver gene mutations develop into tumors, the mechanism of clonal selection within cells that have acquired driver gene mutations remains poorly understood.
Clonal expansion markedly alters the rate at which a tumour acquires driver mutations (Luebeck and Moolgavkar 2002; Hornsby et al. 2007), and so including this phenomenon is likely important.
The somatic mutation profile of a tumour may contribute to this; for example, tumours harbouring or acquiring driver mutations in ESR1 [ 67] or ERBB2 [ 37] or amplifications at 8p12 (FGFR1) or 11q13 (CCND1) [ 23] may be less responsive to targeted endocrine therapy.
The temporal dynamics of probabilities P ij (t), i = 0, 1, …, N, where N is the maximal number of additionally acquired drivers and j = 0, 1, are described by: d P i j (t ) d t = P i j + u P i j (u ) + v P i j (v ).
Ongoing genomic instability in cells such as CICs can subsequently allow for outgrowth of unique subclones, which acquire additional driver mutations that endow them with a selective growth advantage (Hanahan and Weinberg, 2011).
As has been recently shown in acute lymphocytic leukaemia (Greaves, 2009), it is speculated that precancerous melanocytes already harbouring an unknown first hit may subsequently acquire multiple driver mutations; thus, the acquisition of BRAF mutation might be one of these secondary events.
Ms. Vespe finally acquired a driver's license and drove the Plymouth, while Mr. Vespe commuted in the Karmann Ghia, which by then had begun to rot.
Months prior to reassuring the clerk that my pineapple to egg ratio would work out just fine, I had acquired my driver's license.
