This may be attributable in part to quiescent LSCs residing in the protective niches that acquire additional mutations over time.
Proteins can acquire additional domains over time through several mechanisms, including gene fusion, exon extension, exon recombination, intron recombination and retrotransposition [ 4, 9].
An important consideration is that patients may acquire additional risk factors over time, which would necessitate a reassessment of their overall risk profile.
We allow several months for this process because we may need to speak to customers multiple times to acquire additional data and to clarify what they've told us.
Moreover, opponents contend that Asbury Partners has spent more time trying to acquire additional property rather than proceeding with development on the land they now own.
The authors suggest that the long latency period to tumorigenesis in the p53 Ser23 mice provides the time required to acquire additional genetic changes to develop B cell tumors.
In this paper there was a single assessment of risk at baseline but it is important to remember that, over time, individuals may acquire additional risk factors with changes in symptoms, family history or follow-up investigations.
Strategies for acquiring additional curriculum time include utilizing teaching modules that fit into a variety of teaching contexts (e.g., morning report, noon conference, Grand Rounds, case discussions, etc).
"We may, from time to time, propose business strategies and, subsequent to the expiration of the offer, acquire additional shares," Tracinda said in a statement.
Turnaround time on claims processing will release valuable capital reserves that can be used to acquire additional new insurance business.
This will enable us to acquire additional information about maintenance.
