CXC chemokine receptor 4 (CXCR4) is one of 19 acknowledged chemokine receptors and belongs to the family of G-protein coupled chemokine receptor [ 10].
Of note, the expressions of Dll4 and its acknowledged known receptors (Notch1 and Notch4) are relatively restricted to the vascular system, where several studies have shown that Dll4/Notch signaling is crucial [7], [8], [30], [31].
To date, stromal derived factor-1α (SDF-1α)/CXCL12 and its receptor CXCR4 have been acknowledged to be the primary ligand-receptor pair for EPC chemotactic activity.
The present review will focus on those receptors with acknowledged function within the mammary gland.
We must acknowledge that EGFR receptor expression in a tumour does not prove that its function is important for tumour growth, nor that inhibition will automatically result in cell death or therapeutic effect.
Vitamin D receptor activation has acknowledged antiangiogenic properties [ 25].
She likewise acknowledged the role of oestrogen receptor and HER2 in targeted therapy, and further discussed gene expression arrays such as OncotypeDX for targeting treatment.
SNAREs (soluble NSF-attachment protein receptors) are generally acknowledged as central components of membrane fusion reactions, but their precise function has remained enigmatic.
It is universally acknowledged that exposing cell-surface receptors to detergent is detrimental.
While the importance of vitamin D for skeletal health has long been acknowledged, more recent discovery of receptors for vitamin D in multiple organ systems in the body, including immune cells, suggests that the health benefits of vitamin D may extend beyond its classic effects [ 12].
