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A critical role for the ER in calcium signaling was acknowledged before such a role for the mitochondria was widely accepted, in part because the low affinity of Ca2+ channels localized to the outer mitochondrial membrane seemed to fly in the face of this organelle's purported responsiveness to changes in intracellular Ca2+ flux.
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In 2006, Zahorchak said he supported requiring high-school students to pass exit exams before they could graduate, although he acknowledged implementing such a testing program would be a long and difficult effort.
While those experts would have acknowledged that such an attack would have grave results, before 9/11, relatively few people worried about such low-probability, high-consequence security events.
Donaghy acknowledged providing such information to gamblers.
McBride acknowledged that such tactics hurt Labour.
They have acknowledged no such thing.
He acknowledged that such analyses have limitations.
Tavi acknowledged that such arrangements could create complications.
But Alfonzo acknowledged that such moves usually lift a team.
Both individuals have acknowledged that such terms are not acceptable.
The Obama administration has not acknowledged any such understandings.
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