The phrase "acidic stores" is correct and usable in written English.
It can be used in contexts related to chemistry, biology, or food science, referring to places or containers that hold acidic substances.
Example: "The laboratory has several acidic stores where we keep our chemical reagents safely."
Alternatives: "acidic containers" or "acidic reserves".
The LRRK2-mediated effects involve activation of nicotinic acid adenine dinucleotide phosphate (NAADP -sensitive two-pore chaNAADP -sensitiveated on acidic stores, and channelslocked by a specific anTPCsnist.
Hence, lysosomes and other acidic stores, such as secretory granules, are referred to as small Ca2+ stores.
Acidic stores (e.g., endosomes, lysosomes, secretory granules and lysosome-related organelles) can also undergo regulated Ca2+ release (Morgan et al., 2011) (Fig. 1).
In acidic stores inhibition of either pair of RyR1/3 or TPC1/2 abolished responses.
In this respect, the vesicular nature of acidic stores may be an important determinant of outcome.
Moreover, activation of the ADP-ribosyl cyclase CD38 was also required to initiate the release of Ca2+ from acidic stores.
To the best of our knowledge, TPEN has not been previously used to investigate NICR or indeed Ca2+ release from any acidic store.
That TPCs are found on cytolytic granules agrees with the NAADP acidic store pharmacology because cytolytic granules are the acidic, secretory lysosomes of CTL and natural killer (NK) cells [ 25, 29].
For example, in atrial myocytes it has been proposed that NAADP evokes Ca 2+ release from an acidic store, which enhances general SR Ca 2+ release by increasing SR Ca 2+ load and activating RyR sites.
In addition to acidic store alkalinization, it has been shown that fertilization of sea urchin eggs led to a change in cytosolic pH from 6.9 to 7.3 with a concomitant acidification of the sea water, and that the egg remains alkaline for approx. 60 min [ 48, 49].
Unfortunately, this study was flawed because it was not then known that NAADP targets acidic Ca2+ stores and the luminal Ca2+ was manipulated with ionomycin [9] which does not act at acidic Ca2+ stores [36].
