The phrase "acidic milieu" is correct and usable in written English.
It can be used in contexts related to chemistry, biology, or environmental science to describe an environment or setting that has a low pH or is characterized by acidity.
Example: "The acidic milieu of the stomach is essential for the digestion of food and the absorption of nutrients."
Alternatives: "acidic environment" or "acidic setting".
For example, animal studies have shown that within an acidic milieu pepsin potentiates the degree of acid-induced injury to oesophageal epithelial cells, but that at neutral pH pepsin is inactive and its oesophageal epithelial toxicity is ameliorated [ 28].
The resulting acid-sensitive cationic nanoparticles spontaneously disassembled over time in acidic milieu, as investigated by dynamic light scattering.
From these studies, we proposed that this last step of chlorophyll breakdown should occur non-enzymatically in the acidic milieu of the vacuoles, in which the free propionic acid function would be largely protonated.
The inhibition of P. acnes growth and metabolism by FAC could be related to the creation of a superficial acidic milieu, as well as restoration of the skin's acid mantle and commensal microbiome.
LbL-LNPs are pH-sensitive, indicating that intracellular drug release can be increased by the acidic milieu of cancer cells.
Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides.
In combination therapy for tuberculosis, the main population of M. tuberculosis is susceptible to INH, while pyrazinamide is effective against slower growing bacilli in acidic milieus, and rifampicin against nonreplicating bacilli.
A new delivery system (ACIDFORM) was designed with acid-buffering, bioadhesive, and viscosity-retaining properties to (1) maintain the acidic vaginal milieu (the low pH inactivates many pathogens and spermatozoa), (2) form a protective layer over the vaginal/cervical epithelium (minimizing contact with pathogenic organisms), and (3) provide long-term vaginal retention.
Frequently tumor tissue possesses an acidic extracellular milieu because of the disordered metabolic and nutritional environment [20], [21], [22].
The acidic gastric milieu has been discussed to play an important role in nitration as nitrous acid was found to be formed exclusively at low pH, having then the ability to nitrate tyrosine residues of ingested proteins [33].
However, unlike the acidic intragranular milieu of secretory granules [80], [81] the pH of the ER is maintained ∼7.4 [82] [84], and at this physiological pH, chromogranin A fails to bind the IP3Rs directly and only chromogranin B remains bound to the IP3Rs [75] (Fig. 7).
