Generally, these viruses did not show much amino acid variation.
This includes the development of large saturation mutagenized populations, virtually exploring any amino acid variation along the encoded proteins.
Interestingly, the correspondent amino acid variation was localized within the predicted coiled-coil domain of the putative Pi-km1 protein.
The antibody paratope of felines showed similar amino acid variation when compared to human, mouse and canine counterparts.
Actually, there was only a single amino acid variation at position 537 between AP8 and AP9 (Table 3), implying their tight evolutionary relationship.
We measured amino acid variation for the E protein by calculating the Shannon entropy at each position between Asian and American genomes.
Furthermore, during selections, high throughput sequencing enables quantitative tracing of enriched clones and position-specific guidance to amino acid variation under positive selection during antibody engineering.
In total, 30 HLA-associated amino acid variation sites were listed.
As for the internal proteins, NS1 also demonstrated remarkable amino acid variation between lineages.
In silico analysis of the p.I663V amino acid variation suggested this variant might be benign.
To analyze gene-specific amino acid variation, the Shannon entropy per site was determined for each individual gene.
