Although recent application of automated microfluidic ChIP (AutoChIP) was successfully performed using 2 000 cells through locus-specific analysis by qPCR, such assays do not achieve the comprehensiveness afforded by DNA sequencing approaches.
Rather, we prefer a generalised definition of complementarity, which states that the concept is effectively about how conservation actions work synergistically together, to achieve the objectives of comprehensiveness and adequacy in an efficient manner (Moilanen, 2008).
The studies that need to be identified tend to be extremely diverse in both their focus and design, and the problem of achieving both comprehensiveness and precision soon becomes intractable [ 10].
Regular discussion of the most recent findings were organised to refine the analysis and reconcile any discrepancies to achieve consensus, thus increasing the comprehensiveness and rigour of the results.
In this study the aim was to achieve maximal comprehensiveness through setting forth very loose criteria for ligand definition (as described in "Methods" section), with an upper bound for the molecular size of 485 atoms.
To achieve comprehensiveness, data are collected from TCGA, the Curated Short Read archive (CSR) (35), ICGC (12), Gene Expression Atlas (30) and publications (Table 1).
An individual, at least, may feel that this or that view will not do precisely because it achieves comprehensiveness by turning its back on fact; and, though it is unsatisfactory to fall back on personal judgment in this way, there is perhaps no other alternative in this difficult area.
In select studies such as evolutionary genomics, it is not necessary to achieve comprehensiveness; instead, a limited amount of information is sufficient.
In fact, for our purpose the data contained in the grey literature prove very valuable in achieving our aim of comprehensiveness and reduces publication and selection bias.
Although the interest in measuring migration policies has gained momentum, there is still a lack of fundamental methodological discussions about the inherent trade-off between the desire to achieve a large historical (longitudinal) and geographical (cross-sectional) coverage on the one hand, and the comprehensiveness of policies that can be examined on the other.
