Sentence examples for achieving potency from inspiring English sources

All the 67 examined compounds showed high MAO-B selectivity, some of them achieving potency in the low nanomolar range.

8 Our aim was to design and develop a probe for the BRD7 and BRD9 bromodomains, achieving potency and selectivity with a suitably decorated fragment 9 rich in sp-hybridized carbon atoms that, guided by biophysical assays, was designed to maximize specific binding interactions whilst retaining synthetic tractability.

An HIV antibody achieves potency and breadth by binding simultaneously to two conserved glycans on the viral envelope protein.

20 To date, druglike molecules have only achieved potencies in the low micromolar range, 6 unfortunately this remains true for the BTCP series.

The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency.

The binding difference between 3, 4 and 5, 6 argues the importance of the carboxylic group in achieving higher potency NT(8 13) mimetics.

This suggested that the 4- N-methyl piperazine functional group is important for achieving cellular potency.

Synthetic triterpenoids have been produced with the aim of achieving increased potency [ 19, 20].

Achieving sufficient potency to inhibit essential T. brucei kinases, while avoiding related human kinases, poses a significant challenge.

In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10−4 M.

Traumatic events achieve their potency by fusing memory and intense emotion.