Sentence examples for achieving immune from inspiring English sources

This includes a variety of issues related to the cells to be employed, a strategy for achieving immune acceptance, if allogeneic cells are to be used, methods for delivering the therapy, and a manufacturing process that supports moving the concept into clinical studies and ultimately commercialization.

Most cases have shown successful outcomes, achieving immune reconstitution, restoration of thymic activity, systemic detoxification, and long-term engraftment.

Moreover, the higher diversity unveiled by neutral typing techniques compared with antigen sequence typing could suggest positive selection for strains achieving immune escape because of their antigenic profile.

Key questions remain, including the mode of achieving immune modulation (vaccine? immune suppression modulation? TAAs?), timing of immune therapy according to stage of disease, sequence of treatments, and which candidate treatments might best be paired with immune therapy.

As the electric field in the tissue depends on tissue properties and anatomy (i.e., geometry), it is important to define target tissue, which is relatively easy in case of tumors and electrochemotherapy, but less in the case of gene electrotransfer aiming at achieving immune response [ 62].

Now that technologies for cell purification and protocols for expanding specific subsets are more advanced, there are opportunities for achieving immune homeostasis by infusion of regulatory cell populations, some of which may harbour the capacity to repair tissues at sites of inflammation.

Because CD8 cytotoxic T cells are thought to play a pivotal role in achieving immune-mediated tumour destruction, cross-presentation of exogenous antigen to the MHC class I pathway is an important event.

For example, immune responses in phase I and II clinical trials to an MVA-based vaccine developed by Bavarian Nordic (Imvamune®) are dose-dependent and can require two immunizations to achieve immune responses similar to first-generation vaccines., Genetic manipulation of the VACV genome has also played a role in the development of highly attenuated VACV strains.

Another promising strategy to achieve immune destruction of cancer cells is to abolish inhibitory signals that block T cells from killing the targets they recognize.

Our data indicate the possibility of a clinical role held by IL-2 in enhancing the immune function of subjects unable to achieve immune competence through cART alone.

For such patients, "booster" transplants from the same or different donors have been given in efforts to achieve immune reconstitution.