Indeed, because selective modulation of P-gp in cancer cells (and not at physiologic sites) will be difficult to achieve, attempts to circumvent MDR will need to consider the profound effects on the pharmacokinetics and distribution of concomitantly administered drugs.
They are all biomaterials conceived and prepared in situ, a procedure which follows a kind of Occam's razor: making biological engineering simple can be best achieved attempting to keep it simple [ 21] by applying nature's original technology.
If we fail to achieve or attempt to achieve cultural harmonization then economic globalization will create unimaginable conflicts.
Financial and social supports from local governments would be helpful for FCs to achieve this attempt.
In this section, we calculate the optimal deterministic delay, d opt, that achieves optimal attempt rate β opt.
For this target, the novel laminated CuO/ZnO p n heterostructured systems are introduced to achieve this attempt.
She paused to enjoy the moment she had worked so hard to achieve, then attempted to pull open the heavy iron door.
Davros, realising that his creations have achieved sentience, attempts to destroy the bunker, but he is shot by a Dalek.
Taken together, these could swamp any savings achieved by attempts to reduce misuse, abuse or fraud or increase efficiency in the medical care delivery system.
Internal validity was achieved by: attempting to account for non-specific effects of treatments in both groups; absence of assessment bias; and preventing contamination [51], [52].
