The phrase "achieving affinity" is correct and usable in written English.
It can be used in contexts where one is discussing the process of developing a close relationship or connection, often in fields like psychology, marketing, or interpersonal communication.
Example: "The team focused on achieving affinity with their audience to enhance customer loyalty and engagement."
Alternatives: "establishing rapport" or "building connection".
B cells expressing those mutated IGHV genes that have higher antibody affinity are preferentially selected to proliferate in germinal centres in the presence of antigen loaded follicular dendritic cells and follicular B helper T cells thus achieving affinity maturation of the antibody response (Vinuesa et al, 2005).
While the use of substrate and transition-state analogues as a starting point for inhibitor design is common, the rationale there is one of achieving affinity: because substrates and transition-states bind to the target, their analogues could bind as well.
The present work describes the discovery of new retro di- and tripeptide hybrids that do not necessarily require an electrophilic "warhead" to achieve affinities in the low micromolar range.
One of the best studied sialic acid interactions is the influenza virus trimeric haemagglutinin, which can achieve affinities up to 10 M−1 compared with around 4 × 10 M−1 when one or both units are not in a multivalent state (Mammen et al, 1998).
Thus, in these cases, multivalent interactions of individual glycoproteins with individual receptor oligomers have a limited role in achieving high affinity.
On the basis of X-ray co-crystal structures of matrix metalloproteinase-13 (MMP-13) in complex with its inhibitors, our structure-based drug design (SBDD) strategy was directed to achieving high affinity through optimal protein ligand interaction with the unique S1″ hydrophobic specificity pocket.
Since antigen dimerization with PEG spacers will not serve as a general solution to achieving high affinity antibody binding, we turned to a different strategy in which the ligands are displayed as oligomers rather than discrete dimers.
Though this level of binding enhancement is still far less than what one would expect from an ideal linker that supported full cooperativity, it is the best reported in the literature so far for antibodies or other dimeric proteins and was attractive to us as a strategy for achieving higher affinity with our antibody ligands.
The proposed antidote for dabigatran is the antibody aDabi-Fab that achieves an affinity for dabigatran 350 times stronger than its affinity for thrombin.
We describe concepts and methodologies for generating "Affinity Clamps," a new class of recombinant binding proteins that achieve high affinity and high specificity toward short peptide motifs of biological importance, which is a major challenge in protein engineering.
In case of ALX-0061, approximately a 200-fold gain in affinity for sIL-6R compared to the parental Nanobody was achieved through affinity maturation.
