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For example, when testing against random controls, our method successfully ranks known disease genes at the top of a total of 100 candidate genes in 57.42% (820 of 1,428) test cases, achieving a fold enrichment of 57.42% × 100 = 57.42 (p = 57.42%, m = 100).
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Only signatures achieving a fold-change of at least two-fold are listed.
On one hand, we added SM to wt synaptosomes achieving a 2.1- fold increase in the lipid levels of synaptic membranes similar to the ASMko situation (Fig 3Ca) (see methods and Camoletto et al, 2009).
After achieving a 77-fold increase in specific activity, continued purification decreased the yield to 21-fold with 7.2% recovery (specific activity 2575 collagen degrading units mg−1protein) possibly due to removal of co-factors.
The SS-P/PANi anode performed efficiently in a MFC, achieving a 13-fold higher current generation than with a pristine SS-P anoduringing the startup phase.
Expression from DNA-launched and VRP-packaged replicons containing riboswitches was successfully regulated, achieving a 47-fold change in expression and modulation of the resulting type I interferon response.
We carefully profile a CNN implementation on a Raspberry Pi device and optimize the structure of the neural network, achieving a 17-fold speedup without significantly affecting recognition accuracy.
To test this theory, we used siRNAs to reduce gankyrin expression in Lmna−/− cells (Lmna−/−-siGank), achieving a ten-fold reduction compared to siRNAs targeted to a control gene, enhanced GFP (Lmna−/−-siEGFP) (Figure 4A).
This way, 16 P1 and three P2 adapters allow for multiplexing of 48 individuals, while achieving a 2.5-fold cost reduction for adapter generation.
These cell-laden streams were sorted at 70,000 cells/s by splitting the channel, achieving a 300-fold enrichment of bacterial cells with more than 99% purity [ 72].
The analyses of the real datasets revealed that the maximum difference approach required less than three experiments to learn an optimal model, achieving a 5 11-fold improvement over the respective sets of available experiments.
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