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Similarly, when validating the prediction of new CTD relationships under the MAP metric, the strongest performing comparison score achieves MAP of 0.94, while the number of gene terms and the number of disease term bibliometric baselines achieve MAP of 0.88 and 0.78, respectively (Table 7).
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Thus, once this initial MAP target is achieved, MAP should be titrated up or down based on the measures of organ function and tissue perfusion.
We analyzed the changes in transpulmonary thermodilution variables associated with the increase in mean arterial pressure (MAP) induced by norepinephrine when the achieved MAP was ≥65 mm Hg.
The achieved MAP was >85 mm Hg in 16% of patients.
We found that the fluid bolus, achieving MAP >65 mmHg, and lactate clearance were independent predictors of outcome.
The development of new technologies may help clinicians to evaluate, at the bedside, the impact of achieved MAP targets on microcirculatory parameters and organ function.
Because of the observational nature of the study, we were able to analyze only time points when the achieved MAP value was ≥65 mm Hg.
Additionally, we found that, in most patients in whom traditional resuscitative endpoints were achieved (MAP ≥ 65 mmHg, ScvO2 ≥ 70%), IAP and APP were not.
It must be stressed that only 16% of patients had an achieved MAP ≥85 mm Hg, a value that is generally considered the average MAP of the normal population [ 23].
Half of our patients had an achieved MAP ≥75 mm Hg, a value that can be judged relatively high, although it was still far lower than the average MAP of the normal population (>85 mm Hg) [ 23].
In severe sepsis patients with hemodynamic stability, reflected by optimized baseline CVP and ScvO2, the bundle items of fluid bolus administration, achieving MAP >65 mmHg, and lactate clearance were independent predictors of outcome.
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