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MuTect and Strelka achieved the highest specificity.
The combination of age ≥ 5 years, severe dehydration, and an increased (≥ 25) number of stools per 24 hours achieved the highest specificity (99.5%, 95% CI: 98.3 99.9) and PPV (92.0%, 95% CI: 75.0 97.8).
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The specificity across all systems was comparable with Xpert® achieving the highest specificity (100%%).
Nevertheless, the proposed method achieves the highest specificity value which measures fraction of predicted clusters that match benchmark complexes.
Although sufficient to ensure binding, these linear motifs alone are usually too short to achieve the high specificity observed, and additional contacts are often encoded in the residues surrounding the motif (i.e. the context).
IgM specific to Sip1 C-ter achieved the highest prevalence and the highest specificity in patients with BD and with vasculitis.
In our results, PET analysis alone achieved the highest sensitivity and specificity rates (94% and 91%) and was higher than that reported in the literature.
Correlating PS-based prognostic group with histology-based group, observer A achieved the highest 'accuracy' of 69% (sensitivity 73%; specificity 64%), with a PPV (for 'poor' prognosis) of 72%.
Orphelia achieved the highest sensitivity, 90.21%, but the lowest specificity, 22.13%.
This cutoff was used to achieve the highest possible specificity (1.00) with an acceptable corresponding sensitivity (0.64).
The greatest challenge in cancer treatment is to achieve the highest levels of specificity and efficacy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com