Sentence examples for achieved systemically from inspiring English sources

Although it is tempting to speculate that the efficacy of the most effective PAD4 inhibitors, identified in this screen, minocycline and other tetracycline derivatives, is due in part to their ability to inhibit cellular PAD4, we note that it is not clear whether the high concentrations of compound needed to inhibit PAD4 in vitro could be achieved systemically.

Is the theoretical benefit of additional agents such as oxaliplatin outweighed by the increase in acute toxicity, or disguised/diluted by the short-term duration of weeks rather than months and the failure of current regimens to achieve systemically active doses?

Moreover, significant inhibition of tumour growth is achieved when delivered systemically in multiple mouse models of prostate cancer.

The inhibiting effect of TR in both tumour models was achieved when administered systemically p.o. at low concentrations, similar to those that effectively inhibited angiogenesis in vivo.

Simultaneous rejuvenation of myogenesis and hippocampal neurogenesis and reduction of inflammation (Beta 2 Microglobulin, B2M levels) in the same old animal have been achieved by one systemically applied TGF-beta receptor inhibitor, and confirmed by genetic approaches [ 6].

The possibility that tumor cells can achieve this appropriation systemically before they arrive at the site further highlights the therapeutic potential of targeting ECM remodeling to prevent the metastatic dissemination of solid tumors.

To demonstrate that similar effects could be achieved at the BBB, they systemically administered the AAV 2/9 anti-claudin-5 shRNA followed by doxycycline induction.

In cancer this is mainly achieved by chemical drugs that are systemically administered to reach effective toxic doses.

In all preclinical studies, a total regression of all tumors was not achieved when SC vectors were administered systemically.

This can be achieved by combining antigen-specific interventions with systemically acting agents.

In an animal study of neuropathic pain using the sciatic nerve constriction model, Suzuki et al. [ 12] showed that greater analgesia could be achieved with opioids delivered intrathecally rather than systemically.