Sentence examples for achieved site-specific from inspiring English sources

By delivering CRISPR/CRISPR-associated protein 9 (Cas9) ribonucleoprotein (RNP) complexes under conditions of rapid B cell expansion, we achieved site-specific gene disruption at multiple loci in primary human B cells (with editing rates of up to 94%).

We achieved site-specific cannulations 72% of the time for the VTA.

A second phase of genetic modification then achieved site-specific integration of Vida3, a synthetic anti-malarial gene.

We achieved site-specific labeling of different recombinant proteins at the C-terminus both in vitro and in vivo on cell surfaces.

Finally, we successfully achieved site-specific insertion of mloxP sequence induced by Cas9/gRNA system in zebrafish embryos.

In this protocol, we provide detailed, step-by-step instructions for generating new hybrid recombinases with user-defined specificity, as well as methods for achieving site-specific integration into targeted genomic loci using these systems.

These NPs were then surface conjugated with FA in order to achieve site-specific targeting.

Temperature-sensitive liposomes are considered to be a promising tool to achieve site-specific delivery of drugs.

In this chapter, we have explored the strategies and advances made toward the development of polymeric nanocarriers in order to achieve site-specific gene delivery.

An advanced subset of prodrugs can be engineered such as to achieve site-specific bioconversion of the prodrug – to comprise the highly advantageous "enzyme prodrug therapy", EPT.

Bacterial cleavage of azo bonds in sulfasalazine in the intestine can favourably achieve site-specific release of the anti-inflammatory sulfapyridine and 5-aminosalicyclic acid (Peppercorn and Goldman, 1972).