The phrase "achieved significant changes" is correct and usable in written English.
You can use it when discussing accomplishments or improvements that have had a notable impact in a particular context, such as business, personal development, or social movements.
Example: "The organization achieved significant changes in its policies, leading to better employee satisfaction and productivity."
Alternatives: "made substantial improvements" or "brought about major transformations."
A sensitivity analysis conducted for the parameters of a typical baseline system achieved significant changes in rolling noise only for reductions in wheel/rail contact stiffness, increases in wheel/rail contact area, and decreases in wheel/rail roughness through wheel truing and rail grinding.
The second study 15, a 12-week study, showed that doses of 50, 100, 200 or 300 mg canagliflozin once daily, or 300 mg twice daily, achieved significant changes in HbA1c of −0.79, −0.76, −0.70, −0.92 and −0.95%, respectively, compared with −0.22% for placebo (all p < 0.001) and −0.74% for 100 mg sitagliptin once daily.
Critics say Mr. Clinton could have devoted his charisma and the power of the presidency to achieving significant changes in the political money game.
However, these limited in situ improvements in housing are not sufficient to achieve significant changes in the living conditions of the urban poor and to significantly reduce the various ailments they suffer as slum dwellers.
"Arguments related to environmental harm have not had sufficient strength to achieve significant changes in anti-drug policies in the past," he said.
From 2010-2014, Dixon served as the Director of the Law & Security program for Human Rights First where he led efforts to align U.S. counterterrorism policies with the rule of law, achieving significant changes in policy and practice regarding Guantanamo, torture and armed drones.
In this way, the program to educate children about their health -- in Spain it is called SI, but it is also underway in Colombia and soon will appear in the United States -- has already been able to achieve significant changes in the behavior of the young.
Furthermore, the mice treated with DOX took several weeks longer to achieve significant changes from baseline compared to those mice treated with placebo.
RBM can be defined as a "broad management strategy" aimed at achieving significant changes in the way public and private sector actors (institutions, agencies, projects/plans) operate, with improving performance (i.e. achieving better results) as the primary goal.
