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A very similar reduction was achieved in a randomized, placebo-controlled study (MIGR-003) with topiramate [19].
Similar results were achieved in a randomized controlled trial of overweight subjects with impaired glucose tolerance in Finland [ 5].
Homogeneity between treatment and control group characteristics may be achieved in a randomized controlled trial, although the NIH public mandate precludes such an experimental design from being conducted.
A remarkably high rate of blood pressure control was achieved in a randomized, placebo controlled trial using perindopril 2 mg combined with indapamide 0.625 mg as active treatment during 1 year among elderly patients with essential or isolated systolic hypertension.
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Up to date, median survival beyond 12 months has not yet been achieved in any randomized study with combination chemotherapy [ 4].
This is difficult to achieve in randomized trials [ 19] other than pragmatic randomized trials [ 23].
Phase 2 cancer chemoprevention trials are designed to provide estimates of the efficacy of an agent at a specified dose, and the expected size of the risk reduction that may be achieved in a subsequent phase 3 randomized trial.
Nothing can be achieved in a vacuum.
A similar high proportion of responders have only rarely been achieved in other randomized trials of insulin treatment in type 2 diabetes besides in the advanced insulin regimens groups in the 4T trial (6).
Those positions with significantly conserved folding signals (p-value < 0.001 with respect to randomized selection conservation values, Benjamini-Hochberg false discovery rate = 0.001) which had conservation levels higher than achieved in all corresponding randomized variants were defined as positions that undergo a conserved evolutionary selection for strong/weak folding (MFE-selected positions).
The results can then be compared to those achieved in randomized controlled trials of vaccine efficacy in healthy adults which can be considered an upper bound for vaccine effectiveness.
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CEO of Professional Science Editing for Scientists @ prosciediting.com