Nevertheless, mainly due to the high final biomass concentration achieved, fed-batch cultivation B3 yielded a PGA volumetric enzyme activity equivalent to 89000 IU L-1 within 24 h of induction, corresponding to a productivity of 2393 IU L-1 h-1 (or 3680 IU L-1 h-1, considering the elapsed induction period).
The mixing of the material in the reactor was significantly better in fed-batch than batch mode, and similarly high or higher ethanol yields were achieved in fed-batch mode compared with batch SSF in some cases.
Finally, 600 mg/L of CoQ10 production was achieved in fed-batch fermentation.
In addition, compared to the batch culture, a much higher maximum hydrogen production rate (102.33 ml H2/l h) was achieved during fed-batch culture.
A titer of 8.69 g/L diacetyl, the highest reported diacetyl production, was achieved by fed-batch fermentation in optimal conditions using the metabolically engineered strain of Bacillus sp. DL01-ΔalsD-alsS.
A final isopropanol concentration of 9.8 g L−1 was achieved in fed-batch culture on fructose as the sole carbon source (equivalent to 16 g L−1 after taking into account evaporation).
During complete ATR-development, a 25-fold enhancement of volumetric productivity was achieved in fed-batch culture, due to a synergistic combination of increased glucose-feed rates and addition of complex-nutrients to the feed.
By combining improvements in the heterologous mevalonate pathway with a superior fermentation process, commercially relevant titers were achieved in fed-batch fermentations.
High yield of Monascus mycelia with almost no citrinin production were achieved by fed-batch fermentation.
Therefore, we focused more on the variety of integrated color characteristics under high cell density culture, and high yield of Monascus mycelia with a high proportion of yellow pigments was achieved by fed-batch fermentation in this study.
High cell density and carbohydrate accumulation (up to 54% (w/w), mainly starch) were achieved using fed-batch cultures (50 g/L initial glucose and the addition of nitrate pulses).
