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The mDCF regimen achieved efficacy comparable to that of DCF but with fewer toxicities, which is appropriate for the Chinese population.
Common to such extension studies, patients remaining in the study generally represent a self-selected population of those who both tolerated the drug and achieved efficacy.
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Results: The trial was stopped after the planned interim analysis for achieving efficacy endpoints and owing to safety concerns.
Therefore, considerable effort has been put into fine-tuning the properties of antibodies in attempts to achieve efficacy in larger patient populations.
Unless we consider a so-called pro-drug, which requires metabolic activation for achieving efficacy, an otherwise unstable compound usually undergoes attrition during the drug development.
Therapeutics that antagonize the binding of ActRIIB ligands are in clinical development, but concerns exist about achieving efficacy without off-target effects.
The phosphorylated proteins analyzed here represent targets of kinases that should likely be inhibited to achieve efficacy.
And how to achieve efficacy with less rebound possibility?
Furthermore, new monitoring devices are normally introduced into clinical practice without the use of proven protocols to achieve efficacy.
The rationale for this design is based on clinical findings indicating that BCG therapy requires multiple dosing to achieve efficacy.
doses of TAK-875 achieve efficacy as comparable with or better than that of commonly used antidiabetic agents.
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CEO of Professional Science Editing for Scientists @ prosciediting.com