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Studies in heterologous expression systems have shown that BMP7 and BMP6 have the capacity to bind to the same type I and type II BMP receptor subunits [19], although subtleties of binding may be masked by the high concentrations achieved by over expression, potentially concealing receptor specificity that exists in a cell-specific context.
In this study, this goal was achieved by over two thirds of patients on lixisenatide and, importantly, this was possible without any cases of hypoglycaemia.
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A high correlation between the samples is achieved by over-sampling.
In the multivariate context, the proceeds ratio for property sold through foreclosures is significantly lower than the proceeds ratio achieved by over-the-counter sales.
The effect is additive to the reduction in noise exposure achieved by over-ear headphones alone and remains constant over the course of a 24-h period.
Load balancing in Charm++ applications like ChaNGa is normally achieved by over-decomposing the problem into many more objects than processors and letting the Charm++ dynamic load balancing framework balance the load by mapping the objects to processors (Zheng 2005).
The model also predicts that reprogramming the network from a differentiated state, in particular the endoderm state, into a stem cell state, is best achieved by over-expressing Nanog, rather than by suppression of differentiation genes such as Gata-6.
Inhibition rather than absence of RANKL is achieved by over-expression of the natural inhibitor of RANK/RANK, namely osteoprotegerin (OPG).
The activation of STATs in transformed cells is generally achieved by over-activity of tyrosine kinases, either due to an activating mutation in the kinase itself, or as a result of increased signaling by cytokines and growth factors.
As one control for JNK pathway activation, we over-expressed MLK3 at a relatively low level, and even though total cellular levels of this protein did not reach those achieved by over-expression of c-Cbl, there was robust JNK phosphorylation (Fig 5A).
Then, the finer estimation ξ ^ f ( k ) is achieved by searching over ( ξ ^ c ( k ) - 0. 01, ξ ^ c ( k ) + 0. 01 ) with an interval of 10-3.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com