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The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to test whether, for the same achieved blood pressures, regimens based on valsartan or amlodipine would have differing effects on cardiovascular endpoints in high risk hypertension.
For fluconazole, efficacy seems also to be associated with dosage and achieved blood concentrations.
With achieved blood pressure as low as 106/62 mmHg, there was a linear relationship between the logarithm of achieved blood pressure and renal events, suggesting benefit at levels below current recommended targets.
The improved outcomes could also have been due to lower achieved blood pressure in the perindopril-indapamide arm (228).
More intriguingly, the achieved blood pressure in these trials was substantially higher than the target blood pressure.
Safety from hypoglycemia (BG < 2.7 mmol/L) was present despite the lower achieved blood glucose levels during the trials.
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Low adherence to antihypertensive medication is an important barrier to achieving blood pressure control.
To achieve blood supply, EFS organizes mobile blood collection sessions (80% of whole blood supply), close to target blood donors.
In many cases, failure to achieve blood pressure targets may be attributable to the use of antihypertensive monotherapy.
Intervention consisted of a 3-h infusion of HL (30 μmol/kg/min, administered within 48 h from SAH, to achieve blood arterial lactate ≈ 4 5 mmol/L).
Health care providers face many obstacles to achieving blood pressure control, including resistance to taking multiple medications to reach blood pressure goals.
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