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Amphetamines achieve their effect by increasing the amount and activity of the neurotransmitter norepinephrine (noradrenaline) within the brain.
But some writers achieve their effect through an accumulation, or make sense via sentences that are, by themselves, on the far edge of making sense.
Opiates achieve their effect on the brain because their structure closely resembles that of certain molecules called endorphins, which are naturally produced in the body.
Anticoagulants achieve their effect by suppressing the synthesis or function of various clotting factors that are normally present in the blood.
They achieve their effect by covering part of the white area of the eye, the sclera, which ophthalmologists warn could cause allergies, scarring and infection, risking blindness.
Indeed, as mentioned before, several anti-MM drugs, including proteasome inhibitors, IMiDs and atacicept, partly achieve their effect through the neutralization of APRIL.
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They also require a much smaller dosage than barbiturates to achieve their effects.
What Malcolm is really interested in, I think, is not inarticulacy but, rather, the difficulty of describing how certain works of art achieve their effects.
Since these actions can be obtained with other drugs, such as opiates, the distinctive characteristic of sedative-hypnotics is their selective ability to achieve their effects without affecting mood or reducing sensitivity to pain.
All antidepressants, in fact, achieve their effects by inhibiting the body's reabsorption or inactivation of monoamine neurotransmitters, thus allowing the neurotransmitters to accumulate and remain in contact with their receptors for prolonged periods of time; these changes seem to be important in elevating mood and relieving depression.
For both basic pharmacology and drug design it is important to understand the mechanisms whereby these drugs achieve their effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com