Your English writing platform
Discover LudwigSuggestions(1)
Exact(12)
The results so far obtained point out that asymmetric metal environments are essential to reprogram functions, and to achieve the specificity and selectivity of the natural enzymes.
Some recent work has considered flexible target backbone conformations [29], [30] in order to achieve the specificity.
It appears that, with current knowledge of miRNA biology, such methods are unable to achieve the specificity required for whole-genome scans.
These kinases can be further modulated by their assembly with scaffold proteins [6], [17] of which the best known are the JIP protein family [18], thus contributing to achieve the specificity of particular biological effects, depending on cell type [6].
Nevertheless, even within a cellular compartment, several interaction domains and their complementary ligands are regularly expressed at the same time, so more contextual information is required to achieve the specificity observed.
Each physiological subtype is assumed to connect with a selective subset of cholinergic amacrine cells and other presynaptic neurons to achieve the specificity of preferred direction [24]; however, how each subtype is generated and these circuits are organized during development remains totally unknown [25].
Similar(48)
However, there is only one bioinformatics approach regarding the prediction of the hydroxylation modification, which used the bio-kernel SVM model to predict the 37 sequences collected from NCBI [17], [18] and achieved the specificity of 70% and the sensitivity of 90%, but it limited to the prediction of the collagen hydroxyproline [19].
In terms of specificity achieved, the Specificity Terms Filter again performed marginally better.
The design and implementation of spectral simulations depends greatly on the level of complexity needed to achieve the desired specificity in results, tempered by the computational time required.
A plateau effect could however impose a limit on the number of alleles needed to achieve the broadest specificity.
Although sufficient to ensure binding, these linear motifs alone are usually too short to achieve the high specificity observed, and additional contacts are often encoded in the residues surrounding the motif (i.e. the context).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com