This information is vital for accurate prediction of novel instances of these ELMs but it presents an unwelcome challenge for de novo SLiM prediction benchmarking, as it is impossible for computational tools to achieve the same level of specificity given the lack of information in the input data.
This result further supports that the new TFBS predictions achieved essentially the same specificity as the old TFBS predictions while significantly improving the overall coverage of the yeast transcriptional network.
We were unable to achieve the same degree of sensitivity and specificity that we observed with the regression-based predictive model (sensitivity and specificity, 59% and 44%).
In particular, computer-based forms have the potential to achieve the same levels of sensitivity and specificity as their paper-and-pencil counterparts, but by using fewer items on average [ 18, 19].
When compared to HapBlock, for p-value thresholds that achieve the same sensitivity level, MATILDE had about 10% greater specificity, and for the same specificity, nearly half the probability of missing a true effect – a practically important difference especially in screening studies.
Isoform-specificity of PI3K inhibitors are currently designed to achieve the same goal as pan-PI3K inhibitors but without potential adverse effects.
However another possibility is that with a reduction in the efficiency of MTL pattern separation, a greater specificity of meaningful processing is required in older adults to achieve the same level of encoding as the young.
However, no individual ssDNA MRE was able to achieve the same degree of binding affinity as the whole library and ssDNA MRE with high affinity and specificity against K88 fimbriae protein was selected after 11 rounds [ 41].
This means IS-pro cannot achieve the same level of detail as next-generation/whole genome sequencing techniques (e.g. Illumina), although sequence data confirmed specificity of IS-pro in (currently) numerous peaks, underlining the validity of the technique [ 41].
"Could I achieve the same diversity?
