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Up until now, many natural products weren't able to achieve the same efficacy of some synthetic products.
To achieve the same efficacy with fewer adverse effects, several studies testing various modified DCF (mDCF) regimens have been conducted [ 9– 18].
Moreover, we improved the synergy between GEM and PTX to the extent that we could achieve the same efficacy in an animal model as provided by 12 times of the Abraxane dose.
In addition, meta-analysis by Wang and Wu came to a similar conclusion, namely that low-dose intravenous PPI can achieve the same efficacy as high-dose PPI following endoscopic hemostasis [ 22, 23].
Lehoux et al evaluated oritavancin compared to vancomycin in a rat granuloma pouch model study, simulating skin abscesses that are seen in the human host, 6 and found that oritavancin for the treatment of S. aureus skin infections can achieve the same efficacy at daily or less frequent dosing intervals.
For instance, the DRI value of 2.4 for IR in the combination of 1 α,25(OH)2D3 (1 n M) and IR (2 Gy) indicates that to achieve the same efficacy level in the absence of 1 α,25(one2D3, one would have to give 2.4 times higher dose of IR.
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For the subpopulation, we found that much higher values of were required to achieve the same efficacies as in.
For HCC smaller than 2 cm in diameter, radiofrequency ablation (RFA) achieved the same efficacy as surgery [ 4].
However, a recent pharmacodynamics study using dogs showed that drug-soaked lenses releasing 20% of the standard eye drop dosage are capable of achieving the same efficacy as the eye drops.
The development of combination vaccines as well as the improved manufacture of vaccines have resulted in the need for clinical studies seeking equivalence or non-inferiority as investigators seek to demonstrate that combination vaccines achieve the same levels of efficacy, immunogenicity, and safety as their individual counterparts.
Preanaesthetic stress is inversely related to the anaesthetic efficacy, requiring higher doses to achieve the same anaesthetic effect and causing dosage inefficacy [ 17, 18, 41].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com