The phrase "achieve specificities" is not commonly used in written English and may sound awkward.
It could be used in contexts where one aims to attain detailed or precise characteristics or features of something.
Example: "In order to improve our product, we need to achieve specificities that cater to our target audience's needs."
Alternatives: "attain details" or "reach precision".
As for the interaction topologies, the mode of binding and the way to achieve specificity are often specific for each family.
The ensemble pictures of these RNAs suggest that some of the unique conformations can be selected for structure-specific targeting by novel drug molecules to achieve specificity.
To achieve specificity of modification, the "clickable" handle can be genetically encoded into specific ECM proteins.
Our results imply that these pathways achieve specificity by filtering out spurious cross-talk through mutual inhibition.
We show, through modeling, that the physiological response of such pathways exposed to simultaneous and temporally ordered inputs can demonstrate system-level mechanisms by which pathways achieve specificity.
These findings enhance our understanding of the virology of adenovirus infection, and have direct implications for virotherapy vector design, which often rely upon carefully controlled receptor tropisms to achieve specificity and efficacy9,18,28.
The principle underlying this mechanism would be similar to the use of transcription-factor binding sites that have low or modest affinity at enhancers to achieve specificity of gene expression14.
An alternative way to achieve specificity is to use mixtures of compounds and to vary the relative proportions of the components.
Our results show how downstream effectors can decode information contained in the amplitude and duration of Ca2+ signals, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus.
Although signaling dynamics and spatiotemporal mechanisms serve critical roles, it remains unclear if these are the only ways cells achieve specificity within networks.
