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The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2′ pocket.
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We here describe graphene functionalization methods and provide recent examples of how graphene can be used to achieve biological interactions with innovative outcomes.
Each vCell is identified by a template which is used by the manager to create components, allocate resources, reconfigure existing components, and achieve all interactions with the underlying infrastructure and with other vCells.
Comparison of co-crystal structures of parent molecules and fluorinated counterparts revealed the importance of placing fluorine at the optimal position to achieve favorable interactions with protein side chains.
Therefore, it appears that the smaller torsion angle of linker units can achieve better interactions with the active site residues of H+,K+-ATPase to inhibit the acid secretion activity.
The docking studies suggested that the bulky hydrophobic substitution at 3-phenyl ring and the linker of 4-amino-piperidine were beneficial for adopting an active conformation to achieve strong interactions with the active site Mg2+ and the key residue E152 within the catalytic core domain.
These positions could be modified to achieve optimal interactions with the binding pockets.
Avidin-coated particles bind to biotinylated surfaces almost instantaneously due to their extraordinarily high avidity, while antibody-coated carriers perfused over endothelial cells require minutes to hours to achieve sufficient interactions with target cells that allow for firm adherence to the cell.
Reinforcement learning enables learning from feedback achieved through interactions with an external environment.
Functional analysis of the HuAChE active center architecture revealed that accommodation of structurally diverse substrates and other ligands is achieved through interactions with specific subsites such as the acyl pocket, cation binding site, hydrophobic site or the oxyanion hole.
In part, this is achieved by interactions with other signalling pathways.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com