The phrase "achieve efficacious" is not correct in standard English usage.
The term "efficacious" is typically used to describe something that is effective or capable of producing a desired result, but it is not commonly paired with "achieve."
Example: "The new strategy was efficacious in improving team performance."
Alternatives: "achieve effective" or "attain successful".
As a result, in order to achieve efficacious exposures, this younger group might need a higher dosage of daptomycin.
In the current study, we sought to achieve efficacious anti-tumor immunity by disrupting the evident barriers presented by solid tumors in the Rip-Tag model.
Pharmacodynamic models developed from this future data might assist in the estimation of the level of BACE1 inhibition required to achieve efficacious Aβ reduction for a given cerebral amyloid load and level of cognitive impairment.
Alternatively, the potential efficacy and biomarker effects of the antibodies may not have manifested due to limitations in dosing levels or frequency and the failure to achieve efficacious brain concentrations.
As the aim of this trial is to use tDCS to boost the effect of exercise, the intervention duration has been selected based on the number of sessions required to achieve efficacious outcomes using exercise alone in knee OA.
The results suggest that administration of isotretinoin via powder aerosol inhalation is probably superior to its application via the oral route in terms of achieving efficacious drug concentrations in the lungs.
Based on the pharmacokinetic results in this study, a daily dose of 160 mg for 3 days is able to achieve an efficacious exposure AUC0 24 of at least 1,800 ng · h/ml, which is equivalent to the efficacious dose in mice, while a daily dose of 400 mg for 3 days or a single dose of 800 mg is able to maintain a total plasma concentration greater than the MIC for 6 days.
Remote loading of liposomes by trans-membrane gradients is used to achieve therapeutically efficacious intra-liposome concentrations of drugs.
With the goal to achieve highly efficacious MRI-monitored magnetic targeting, a novel drug carrier with dual nature of superior magnetophoretic mobility and superparamagnetism was synthesized.
The model can be used to design compounds with low Vdu values and high fraction unbound in tissues which will minimise the required dose to achieve the efficacious free concentration at the target organ (excluding possible active transport processes).
Understanding these basic distribution patterns and parameters for delivery are important for the design of gene delivery vectors and vital for modeling dose responses to achieve safe efficacious delivery of a therapeutic agent.
