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Multiphoton nonlinear microscopy can achieve deeper imaging depth, while maintaining high 3D resolution [ 23, 24].
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A truncated hyperlens composed of pairs of metal-dielectric cylindrical multilayers is proposed to demagnify the diffraction limited spot to achieve deep subwavelength imaging.
Simultaneously, QDs has a larger two-photon cross section than conventional fluorescent dyes which can avoid the interference of tissue autofluorescence and can help achieve deep tissue imaging [ 13, 20].
These results suggest that two-photon excitation microscopy using fluorophore-conjugated anti-CEA antibody can achieve deeper and more sensitive cancer cell imaging in vivo than conventional imaging using a fluorescence zoom microscope.
CML patients in the chronic phase treated with IM achieve deep and durable responses [ 2].
To avoid generalized muscle contractions, additional rocuronium was given to achieve deep muscle paralysis.
The combination of insignificant scattering of X-rays in tissues, and the high tissue penetration of NIR optical photons emitted from appropriate phosphors, opens up the possibility of achieving deep tissue optical imaging in vivo with unprecedented spatial resolution.
We conclude by reviewing practical challenges to achieving deep inclusion.
Eighteen patients achieved deep molecular remission (MR4.5 or MR4.0).
The relatively slow scan speed was applied in order to increase the SNR and achieve imaging of deeper structures.
Additionally, ongoing work aims to show deeper imaging of photoacoustic-based gene expression in real-time.
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